文献速递 | 9月单细胞测序文章分享

※Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL

※Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma

※Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy

※A cellular hierarchy in melanoma uncouples growth and metastasis

※Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study

Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma.

※Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

※SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages

※Interleukin-18 signaling promotes activation of hepatic stellate cells in murine liver fibrosis

※Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia

※Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice

Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia.

※Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development

※Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation

※Heterogeneity and transcriptome changes of human CD8+ T cells across nine decades of life

※Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

※Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates.

※ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut

※Brainstem ADCYAP1+ neurons control multiple aspects of sickness behaviour

※A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation

※Independent origins of fetal liver haematopoietic stem and progenitor cells

※Chromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers

Independent origins of fetal liver haematopoietic stem and progenitor cells.

※Crossing nerve transfer drives sensory input–dependent plasticity for motor recovery after brain injury

※A "multi-omics" analysis of blood-brain barrier and synaptic dysfunction in APOE4 mice

Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH

Cell type-specific inference of differential expression in spatial transcriptomics

De novo construction of T cell compartment in humanized mice engrafted with iPSC-derived thymus organoids

De novo construction of T cell compartment in humanized mice engrafted with iPSC-derived thymus organoids.